The java/js ecosystem has the largest reach making it the easy choice. One could work on a js compiler and target pouchDB as a starting point. That said choosing js also makes Arc go further down the path Clojure has already gone putting the two closer together, and with Clojure being so far ahead in that arena then maybe it's doomed to fail. The other way to go is to do what Clojure is not great at. iOS development? maybe integration with swift? At any rate I'm not a language development guy. I can only tell you what would appeal to me. I mostly use Clojure and a really easy to use arc->iOS app development ecosystem would be really cool.